ИНТЕРСТИЦИАЛЬНЫЕ КЛЕТКИ КАХАЛЯ: КАЛЬЦИЙ-ОПОСРЕДОВАННЫЕ МЕХАНИЗМЫ РЕГУЛЯЦИИ ФУНКЦИЙ
Аннотация
Обзор посвящен анализу известных физиологических механизмов кальциевой регуляции функции интерстициальных клеток Кахаля желудочно-кишечного тракта. Обсуждены особенности развития, иммунохимические маркеры и типы клеток Кахаля, варианты их локализации в различных органах пищеварительной системы. Показано, что регуляцию моторной активности желудка и тонкой кишки обеспечивает межклеточный функциональный комплекс – SIP синцитий, включающий интерстициальные пейсмекерные клетки, гладкомышечные клетки и интерстициальные PDGFRα+-клетки. ICC желудочно-кишечного тракта, обладающие спонтанной электрической (пейсмейкерной) активностью, необходимы для генерации, распространения, регуляции частоты и амплитуды медленных волн, сопрягая процессы возбуждения и сокращения гладких миоцитов. В основе физиологии пейсмекерных и гладкомышечных клеток лежат механизмы контроля внутриклеточного баланса Са2+: приток ионов из внеклеточного матрикса, высвобождение Са2+ из внутриклеточных хранилищ и его депонирование. Фундаментальным для генерации медленноволнового тока в ICC и сопряжения с сокращением гладких миоцитов является кальций-зависимый сигнальный механизм, включающий последовательную активацию рецепторов (IT3 и рианодина), потенциал-зависимых и ANO-каналов в плазмолемме интерстициальной клетки.
Литература
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6. Baker S. A., Leigh W. A., Del Valle G., De Yturriaga I. F., et al. Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon. eLife. 2021; 10: e64099.
7. Baker S.A., Drumm B.T., Saur D., Hennig G.W., et al. Spontaneous Ca(2+) transients in interstitial cells of cajal located within the deep muscular plexus of the murine small intestine. J. Physiol. 2016;594:3317-3338.
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14. Burnstock G., Lavin S. Interstitial cells of cajal and purinergic signalling. Auton Neurosci. 2002;97:68-72.
15. Choi S., Park D.Y., Yeum C.H., Chang I.Y., et al. Bradykinin modulates pacemaker currents through bradykinin b2 receptors in cultured interstitial cells of cajal from the murine small intestine. Br. J. Pharmacol. 2006;148:918-926.
16. Deng J., He P., Zhong X., Wang Q., Li L., Song B. Identification of t-type calcium channels in the interstitial cells of cajal in rat bladder. Urology. 2012;80:e1381-e1387.
17. Drumm B.T., Koh S.D., Andersson K.E., Ward S.M. Calcium signalling in cajal-like interstitial cells of the lower urinary tract. Nat. Rev. Urol. 2014;11:555-564.
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19. Flores-Soto E., Reyes-Garcia J., Sommer B., Montaño L.M. Sarcoplasmic reticulum Ca2+ refilling is determined by L-type Ca2+ and store operated Ca2+ channels in guinea pig airway smooth muscle. Eur J Pharmacol. 2013;721:21-28.
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21. Godin N., Rousseau E. TRPC6 silencing in primary airway smooth muscle cells inhibits protein expression without affecting OAG-induced calcium entry. Mol Cell Biochem. 2007;296:193-201.
22. Gomez-Pinilla P.J., Gibbons S.J., Bardsley M.R., Lorincz A., et al. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am. J. Physiol. Gastrointest. Liver Physiol. 2009;296:G1370-G1381.
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31. Kim B.J., Kwon Y.K., Kim E., So I. Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J. Physiol. Pharmacol. 2013;17:149-156.
32. Kim B.J., Park K.J., Kim H.W., Choi S., et al. Identification of trpm7 channels in human intestinal interstitial cells of cajal. World J. Gastroenterol. 2009;15:5799-5804.
33. Kluppel M., Huizinga J.D., Malysz J., Bernstein A. Developmental origin and Kit-dependent development of the interstitial cells of Cajal in the mammalian small intestine. Develop. Dyn. 1998; 211 (1): 60-71.
34. Koh S.D., Jun J.Y., Kim T.W., Sanders K.M. A Ca (2+)-inhibited non-selective cation conductance contributes to pacemaker currents in mouse interstitial cell of Cajal. J. Physiol. 2002; 540 (3): 803-814.
35. Komuro T. Comparative morphology of interstitial cells of Cajal: Ultrastructural characterization. Microsc. Res. Tech. 1999;47:267-285.
36. Lee H.T., Hennig G.W., Fleming N.W., Keef K.D., et al. Septal interstitial cells of Cajal conduct pacemaker activity to excite muscle bundles in human jejunum. Gastroenterology. 2007;133:907-917.
37. Lipskaia L., Bobe R., Chen J., Turnbull I.C., et al. Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+-ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells. Circulation. 2014;129:773-785.
38. Liu B., Zhang B., Huang S., Yang L., et al. Ca2+ Entry through reverse mode Na+/Ca2+ Exchanger contributes to store operated channel-mediated neointima formation after arterial injury. Can J Cardiol. 2018;34:791-799.
39. Martinsen A., Dessy C., Morel N. Regulation of calcium chan-nels in smooth muscle: New insights into the role of myosin light chain kinase. Channels (Austin). 2014;8:402-413.
40. Matsuki K., Kato D., Takemoto M., Suzuki Y., et al. Negative regulation of cellular Ca2+ mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth muscle. Am J Physiol Cell Physiol. 2018;315:C1-C9.
41. Mei F., Han J., Huang Y. Jiang Z.Y., et al. Plasticity of interstitial cells of Cajal: A study in the small intestine of adult Guinea pigs. Anat Rec (Hoboken). 2009; 292 (7): 985-993.
42. Metzger R., Schuster T., Till H., Franke F.E, Dietz H.G. Cajal-like cells in the upper urinary tract: comparative study in various species. Pediatr. Surg. Int. 2005; 21 (3): 169-174.
43. Miettinen M., Fletcher C.D.M., Kindblom L.-G., Tsui W.M.S. et al. Mesenchimal tumors of the small intestine. WHO classification of tumours of the digestive system. F.T. Bosman, F. Carneiro, R.H. Hruban et al. (eds.). Lyon: International Agency for Research on Cancer. 2010. P. 115-118.
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2. Егоров В.И., Кармазановский Г.Г., Щеголев А.И., Дубова Е.А., Яшина Н.И., Осипова Н.Ю. и др. Значение предоперационной визуализации для выбора хирургической тактики при гастроинтестинальных стромальных опухолях. Медицинская визуализация. 2007; 2: 34-43.
3. Низяева Н.В., Щёголев А.И., Марей М.В., Сухих Г.Т. Интерстициальные пейсмейкерные клетки. Вестник РАМН. 2014; 7-8: 17-24.
4. Студницкий В.Б., Пелюх П.Ф. Роль некоторых производных мезенхимальной ткани в формировании периодической деятельности пищеварительного тракта. Вестник науки Сибири. 2015. Спецвыпуск (15). 326-332.
5. Avila-Medina J., Mayoral-González I., Domínguez-Rodriguez A., Gallardo-Castillo I., et al. The complex role of store operated calcium entry pathways and related proteins in the function of cardiac, skeletal and vascular smooth muscle cells. Front Physiol. 2018;9:257.
6. Baker S. A., Leigh W. A., Del Valle G., De Yturriaga I. F., et al. Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon. eLife. 2021; 10: e64099.
7. Baker S.A., Drumm B.T., Saur D., Hennig G.W., et al. Spontaneous Ca(2+) transients in interstitial cells of cajal located within the deep muscular plexus of the murine small intestine. J. Physiol. 2016;594:3317-3338.
8. Ball E.R., Matsuda M.M., Dye L., Hoffmann V., et al. Ultra-structural identification of interstitial cells of Cajal in the zebrafish Danio rerio. Cell Tissue Res. 2012; 349: 483-491.
9. Beckett E.A., Takeda Y., Yanase H., Sanders K.M., Ward S.M. Synaptic specializations exist between enteric motor nerves and interstitial cells of Cajal in the murine stomach. J. Comp. Neurol. 2005;493:193-206.
10. Berridge M.J. Inositol trisphosphate and calcium signalling mechanisms. Biochim. Biophys. Acta. 2009;1793:933-940.
11. Beyder A., Farrugia G. Targeting ion channels for the treatment of gastrointestinal motility disorders. Therap. Adv. Gastroenterol. 2012;5:5-21.
12. Blaustein M.P., Lederer W.J. Sodium/calcium exchange: Its physiological implications. Physiol Rev. 1999;79:763-854.
13. Braunstein T.H., Inoue R., Cribbs L., Oike M., et al. The role of L- and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles. J Vasc Res. 2009;46:138-151.
14. Burnstock G., Lavin S. Interstitial cells of cajal and purinergic signalling. Auton Neurosci. 2002;97:68-72.
15. Choi S., Park D.Y., Yeum C.H., Chang I.Y., et al. Bradykinin modulates pacemaker currents through bradykinin b2 receptors in cultured interstitial cells of cajal from the murine small intestine. Br. J. Pharmacol. 2006;148:918-926.
16. Deng J., He P., Zhong X., Wang Q., Li L., Song B. Identification of t-type calcium channels in the interstitial cells of cajal in rat bladder. Urology. 2012;80:e1381-e1387.
17. Drumm B.T., Koh S.D., Andersson K.E., Ward S.M. Calcium signalling in cajal-like interstitial cells of the lower urinary tract. Nat. Rev. Urol. 2014;11:555-564.
18. Dubois Ch., Prevarskaya N., Abeele F.V. The calcium-signaling toolkit: Updates needed. BiochimicaetBiophysicaActa. 2016; 1863:1337-1343.
19. Flores-Soto E., Reyes-Garcia J., Sommer B., Montaño L.M. Sarcoplasmic reticulum Ca2+ refilling is determined by L-type Ca2+ and store operated Ca2+ channels in guinea pig airway smooth muscle. Eur J Pharmacol. 2013;721:21-28.
20. Foong D., Zhou J., Zarrouk A., Ho V., et al. Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility. Int J Mol Sci. 2020 Jun; 21(12): 4540.
21. Godin N., Rousseau E. TRPC6 silencing in primary airway smooth muscle cells inhibits protein expression without affecting OAG-induced calcium entry. Mol Cell Biochem. 2007;296:193-201.
22. Gomez-Pinilla P.J., Gibbons S.J., Bardsley M.R., Lorincz A., et al. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am. J. Physiol. Gastrointest. Liver Physiol. 2009;296:G1370-G1381.
23. Hallam T.J., Rink T.J.. Receptor-mediated Ca2+ entry: Diversity of function and mechanism. Trends Pharmacol Sci. 1989;10:8-10.
24. Hashitani H., Lang R.J. Functions of icc-like cells in the urinary tract and male genital organs. J. Cell. Mol. Med. 2010;14:1199-1211.
25. Hu Z., Ma R., Gong J. Investigation of testosterone-mediated non-transcriptional inhibition of Ca2+ in vascular smooth muscle cells. Biomed Rep. 2016;4:197-202.
26. Huizinga J.D., Thuneberg L., Kluppel M., et al. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature. 1995; 373: 347-349.
27. Hunziker M., Gosemann J-H., O'Donnell A-M., Corcionivoschi N. Altered Anoctamin-1 (ANO 1) Tyrosine Phosphorylation In Congenital Ureteropelvic Junction Obstruction. Conference: 2012 American Academy of Pediatrics National Conference and Exhibition. October 2012.
28. Ibba Manneschi L., Pacini S., Corsani L., Bechi P., Faussone-Pellegrini M.S. Interstitital cells of Cajal in the human stomach: Distribution and relationship with enteric innervation. Histol. Histopathol. 2004;19:1153-1164.
29. Iino S., Horiguchi K. Interstitial cells of cajal are involved in neurotransmission in the gastrointestinal tract. Acta Histochem. Cytochem. 2006;39:145-153.
30. Ito S., Kume H., Naruse K., Kondo M., et al. A novel Ca2+ influx pathway activated by mechanical stretch in human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2008 Apr;38(4):407-413.
31. Kim B.J., Kwon Y.K., Kim E., So I. Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J. Physiol. Pharmacol. 2013;17:149-156.
32. Kim B.J., Park K.J., Kim H.W., Choi S., et al. Identification of trpm7 channels in human intestinal interstitial cells of cajal. World J. Gastroenterol. 2009;15:5799-5804.
33. Kluppel M., Huizinga J.D., Malysz J., Bernstein A. Developmental origin and Kit-dependent development of the interstitial cells of Cajal in the mammalian small intestine. Develop. Dyn. 1998; 211 (1): 60-71.
34. Koh S.D., Jun J.Y., Kim T.W., Sanders K.M. A Ca (2+)-inhibited non-selective cation conductance contributes to pacemaker currents in mouse interstitial cell of Cajal. J. Physiol. 2002; 540 (3): 803-814.
35. Komuro T. Comparative morphology of interstitial cells of Cajal: Ultrastructural characterization. Microsc. Res. Tech. 1999;47:267-285.
36. Lee H.T., Hennig G.W., Fleming N.W., Keef K.D., et al. Septal interstitial cells of Cajal conduct pacemaker activity to excite muscle bundles in human jejunum. Gastroenterology. 2007;133:907-917.
37. Lipskaia L., Bobe R., Chen J., Turnbull I.C., et al. Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+-ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells. Circulation. 2014;129:773-785.
38. Liu B., Zhang B., Huang S., Yang L., et al. Ca2+ Entry through reverse mode Na+/Ca2+ Exchanger contributes to store operated channel-mediated neointima formation after arterial injury. Can J Cardiol. 2018;34:791-799.
39. Martinsen A., Dessy C., Morel N. Regulation of calcium chan-nels in smooth muscle: New insights into the role of myosin light chain kinase. Channels (Austin). 2014;8:402-413.
40. Matsuki K., Kato D., Takemoto M., Suzuki Y., et al. Negative regulation of cellular Ca2+ mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth muscle. Am J Physiol Cell Physiol. 2018;315:C1-C9.
41. Mei F., Han J., Huang Y. Jiang Z.Y., et al. Plasticity of interstitial cells of Cajal: A study in the small intestine of adult Guinea pigs. Anat Rec (Hoboken). 2009; 292 (7): 985-993.
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Опубликована
2021-03-01
Как цитировать
ЕНГЕНОВ, Н. М..
ИНТЕРСТИЦИАЛЬНЫЕ КЛЕТКИ КАХАЛЯ: КАЛЬЦИЙ-ОПОСРЕДОВАННЫЕ МЕХАНИЗМЫ РЕГУЛЯЦИИ ФУНКЦИЙ.
Университетская клиника, [S.l.], n. 1(38), p. 78-87, март 2021.
ISSN 1819-0464. Доступно на: <http://journal.dnmu.ru/index.php/UC/article/view/679>. Дата доступа: 06 июль 2024
doi: https://doi.org/10.26435/uc.v0i1(38).679.
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