СЛУЧАЙ ПАРАЦЕТАМОЛ-ИНДУЦИРУЕМОЙ ГИПОГЛИКЕМИИ
Аннотация
Парацетамол (ацетаминофен) содержится более чем в 500 препаратах, продаваемых без рецепта, а также, назначаемых по рецепту. Парацетамол является одним из самых распространенных фармацевтических продуктов, вызывающих лекарственное поражение печени, и отвечает за почти половину случаев острой печеночной недостаточности. Проанализированы литературные данные, посвящённые причинам, особенностям и клиническим проявлениям данной патологии. Описаны предикторы тяжелого поражения печени.
В работе представлен случай токсического действии парацетамола (ацетаминофена), приведшего к возникновению у пациента лекарственного поражения печени и гипогликемии.
Литература
1. Bunchorntavakul C., Reddy K.R. Acetaminophen-related Hepatotoxicity. Clin Liver Dis. 2013; 17: 587-607. doi: 10.1016/j.cld.2013.07.005
2. Rogalski A.L., Smith K.M. Changing winds: practice implications of acetaminophen regulations. Orthopedics. 2009; 32 (10). doi: 10.3928/01477447-20090818-17
3. Herndon C.M., Dankenbring D.M. Patient perception and knowledge of acetaminophen in a large family medicine service. J Pain Palliat Care Pharmacother. 2014; 28: 109-116. doi: 10.3109/15360288.2014.908993
4. Clark R., Fisher J.E., Sketris I.S., Johnston G.M. Population prevalence of high dose paracetamol in dispensed paracetamol/opioid prescription combinations: an observational study. BMC Clin Pharmacol. 2012; 12: 11. doi: 10.1186/1472-6904-12-11
5. Murray K.F., Hadzic N., Wirth S., Bassett M., Kelly D. Drug-related hepatotoxicity and acute liver failure. J Pediatr Gastroenterol Nutr. 2008; 47: 395-405. doi: 10.1097/MPG.0b013e3181709464
6. Michna E., Duh M.S., Korves C., Dahl J.L. Removal of opioid/acetaminophen combination prescription pain medications: assessing the evidence for hepatotoxicity and consequences of removal of these medications. Pain Med. 2010; 11: 369-378. doi: 10.1111/j.1526-4637.2010.00811.x
7. Blieden M., Paramore L.C., Shah D., Ben-Joseph R. A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States. Expert Rev Clin Pharmacol. 2014; 7: 341-348. doi: 10.1586/17512433. 2014. 904744
8. McGill M.R., Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013; 30: 2174-2187. doi: 10.1007/s11095-013-1007-6
9. Cholongitas E., Theocharidou E., Vasianopoulou P., Betrosian A., Shaw S., Patch D. [et al.] Comparison of the sequential organ failure assessment score with the King’s College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure. Liver Transpl. 2012; 18: 405-412. doi: 10.1002/lt.23370
10. Craig D.G., Ford A.C., Hayes P.C., Simpson K.J. Systematic review: prognostic tests of paracetamol-induced acute liver failure. Aliment Pharmacol Ther. 2010; 31: 1064-1076. doi: 10.1111/j.1365-2036.2010.04279.x
11. US Food and Drug Administration. Acetaminophen and Hypoglycemia. Available at https://www.ehealthme.com/ds/acetaminophen/hypoglycemia/. Accessed: April 08, 2018.
12. Levine M., Pizon A.F., Stellpflug S.J., Wiegand T., Villano J., Peak D.A. [et al.] Hypoglycemia in Acetaminophen-induced hepatic failure: What is the Significance? Annals of Emergency Medicine. 2015; 66 (4), Suppl.: S140.
13. Levine M., Stellpflug S.J., Pizon A.F., Peak D.A., Villano J., Wiegand T. [et al.] Hypoglycemia and lactic acidosis outperform King’s College criteria for predicting death or transplant in acetaminophen toxic patients. Clin Toxicol (Phila). 2018; 5: 1-4.
14. Liu Z.X., Govindarajan S., Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology. 2004;127:1760-1774. doi: 10.1053/j.gastro.2004.08.053
15. Xie Y., McGill M.R., Dorko K., Kumer S.C., Schmitt T.M., Forster J. [et al.] Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol Appl Pharmacol. 2014; 279: 266-274. doi: 10.1016/j.taap.2014.05.010
16. Watkins P.B., Kaplowitz N., Slattery J.T., Colonese C.R., Colucci S.V., Stewart P.W. [et al.] Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA. 2006; 296: 87-93. doi: 10.1001/jama.296.1.87
17. Schmidt L.E., Dalhoff K., Poulsen H.E. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology. 2002; 35: 876-882. doi: 10.1053/jhep.2002.32148
18. Dart R.C., Erdman A.R., Olson K.R., Christianson G., Manoguerra A.S., Chyka P.A. [et al.] Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 2006; 44: 1-18. doi: 10.1080/15563650500394571
19. Marzilawati A.R., Ngau Y.Y., Mahadeva S. Low rates of hepatotoxicity among Asian patients with paracetamol overdose: a review of 1024 cases. BMC Pharmacol Toxicol. 2012; 13: 8. doi: 10.1186/2050-6511-13-8.
20. Mennecozzi M., Landesmann B., Palosaari T., Harris G., Whelan M. Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro? PLoS One. 2015; 10: e0122786. doi: 10.1371/journal.pone.0122786
21. Budden L.; Vink R. Paracetamol overdose: pathophysiology and nursing management. Br J Nurs. 1996; 5: 145-152.
22. Waring W.S., Stephen A.F., Malkowska A.M., Robinson O.D. Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose. Acad Emerg Med. 2008; 15: 54-58. doi: 10.1111/j.1553-2712.2007.00019.x
23. Altomare E., Leo M.A., Lieber C.S. Interaction of acute ethanol administration with acetaminophen metabolism and toxicity in rats fed alcohol chronically. Alcohol Clin Exp Res. 1984; 8: 405-408.
24. Lauterberg B.H., Velez M.E. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut. 1988; 29: 1153-1157.
25. Lystbaek B.B., Svendsen L.B., Heslet L. Paracetamol poisoning. Nord Med. 1995; 110: 156-159.
26. Lee W. Drug-induced hepatotoxicity. New England Journal of Medicine. 2003; 349: 474-485.
2. Rogalski A.L., Smith K.M. Changing winds: practice implications of acetaminophen regulations. Orthopedics. 2009; 32 (10). doi: 10.3928/01477447-20090818-17
3. Herndon C.M., Dankenbring D.M. Patient perception and knowledge of acetaminophen in a large family medicine service. J Pain Palliat Care Pharmacother. 2014; 28: 109-116. doi: 10.3109/15360288.2014.908993
4. Clark R., Fisher J.E., Sketris I.S., Johnston G.M. Population prevalence of high dose paracetamol in dispensed paracetamol/opioid prescription combinations: an observational study. BMC Clin Pharmacol. 2012; 12: 11. doi: 10.1186/1472-6904-12-11
5. Murray K.F., Hadzic N., Wirth S., Bassett M., Kelly D. Drug-related hepatotoxicity and acute liver failure. J Pediatr Gastroenterol Nutr. 2008; 47: 395-405. doi: 10.1097/MPG.0b013e3181709464
6. Michna E., Duh M.S., Korves C., Dahl J.L. Removal of opioid/acetaminophen combination prescription pain medications: assessing the evidence for hepatotoxicity and consequences of removal of these medications. Pain Med. 2010; 11: 369-378. doi: 10.1111/j.1526-4637.2010.00811.x
7. Blieden M., Paramore L.C., Shah D., Ben-Joseph R. A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States. Expert Rev Clin Pharmacol. 2014; 7: 341-348. doi: 10.1586/17512433. 2014. 904744
8. McGill M.R., Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013; 30: 2174-2187. doi: 10.1007/s11095-013-1007-6
9. Cholongitas E., Theocharidou E., Vasianopoulou P., Betrosian A., Shaw S., Patch D. [et al.] Comparison of the sequential organ failure assessment score with the King’s College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure. Liver Transpl. 2012; 18: 405-412. doi: 10.1002/lt.23370
10. Craig D.G., Ford A.C., Hayes P.C., Simpson K.J. Systematic review: prognostic tests of paracetamol-induced acute liver failure. Aliment Pharmacol Ther. 2010; 31: 1064-1076. doi: 10.1111/j.1365-2036.2010.04279.x
11. US Food and Drug Administration. Acetaminophen and Hypoglycemia. Available at https://www.ehealthme.com/ds/acetaminophen/hypoglycemia/. Accessed: April 08, 2018.
12. Levine M., Pizon A.F., Stellpflug S.J., Wiegand T., Villano J., Peak D.A. [et al.] Hypoglycemia in Acetaminophen-induced hepatic failure: What is the Significance? Annals of Emergency Medicine. 2015; 66 (4), Suppl.: S140.
13. Levine M., Stellpflug S.J., Pizon A.F., Peak D.A., Villano J., Wiegand T. [et al.] Hypoglycemia and lactic acidosis outperform King’s College criteria for predicting death or transplant in acetaminophen toxic patients. Clin Toxicol (Phila). 2018; 5: 1-4.
14. Liu Z.X., Govindarajan S., Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology. 2004;127:1760-1774. doi: 10.1053/j.gastro.2004.08.053
15. Xie Y., McGill M.R., Dorko K., Kumer S.C., Schmitt T.M., Forster J. [et al.] Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol Appl Pharmacol. 2014; 279: 266-274. doi: 10.1016/j.taap.2014.05.010
16. Watkins P.B., Kaplowitz N., Slattery J.T., Colonese C.R., Colucci S.V., Stewart P.W. [et al.] Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA. 2006; 296: 87-93. doi: 10.1001/jama.296.1.87
17. Schmidt L.E., Dalhoff K., Poulsen H.E. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology. 2002; 35: 876-882. doi: 10.1053/jhep.2002.32148
18. Dart R.C., Erdman A.R., Olson K.R., Christianson G., Manoguerra A.S., Chyka P.A. [et al.] Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 2006; 44: 1-18. doi: 10.1080/15563650500394571
19. Marzilawati A.R., Ngau Y.Y., Mahadeva S. Low rates of hepatotoxicity among Asian patients with paracetamol overdose: a review of 1024 cases. BMC Pharmacol Toxicol. 2012; 13: 8. doi: 10.1186/2050-6511-13-8.
20. Mennecozzi M., Landesmann B., Palosaari T., Harris G., Whelan M. Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro? PLoS One. 2015; 10: e0122786. doi: 10.1371/journal.pone.0122786
21. Budden L.; Vink R. Paracetamol overdose: pathophysiology and nursing management. Br J Nurs. 1996; 5: 145-152.
22. Waring W.S., Stephen A.F., Malkowska A.M., Robinson O.D. Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose. Acad Emerg Med. 2008; 15: 54-58. doi: 10.1111/j.1553-2712.2007.00019.x
23. Altomare E., Leo M.A., Lieber C.S. Interaction of acute ethanol administration with acetaminophen metabolism and toxicity in rats fed alcohol chronically. Alcohol Clin Exp Res. 1984; 8: 405-408.
24. Lauterberg B.H., Velez M.E. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut. 1988; 29: 1153-1157.
25. Lystbaek B.B., Svendsen L.B., Heslet L. Paracetamol poisoning. Nord Med. 1995; 110: 156-159.
26. Lee W. Drug-induced hepatotoxicity. New England Journal of Medicine. 2003; 349: 474-485.
Опубликована
2019-03-01
Как цитировать
ЧЕБАЛИНА, Е. А. et al.
СЛУЧАЙ ПАРАЦЕТАМОЛ-ИНДУЦИРУЕМОЙ ГИПОГЛИКЕМИИ.
Университетская клиника, [S.l.], n. 1(30), p. 97-101, март 2019.
ISSN 1819-0464. Доступно на: <http://journal.dnmu.ru/index.php/UC/article/view/291>. Дата доступа: 24 апр. 2024
Раздел
Случай из практики
