PATHOMORPHOLOGICAL MANIFESTATIONS OF EXPERIMENTAL APICAL PERIODONTITIS AND THEIR RELATIONSHIP WITH THE CONTENT OF Il-1β IN PERIAPICAL EXUDATE
Abstract
The aim of the study was to investigate the association between the morphological features in periodontitis with the pathomorphological manifestation of experimental apical periodontitis. For the experimental purposes apical periodontitis has been reproduced in 24 root canals in 12 premolars of the mandible. Histological slices were investigated under the light optical microscope Olympus BX- 40. IL-1β was measured by enzyme-linked immunosorbent essays.
It has been found out that the highest level of IL-1β corresponded to chronic lesion in the stages of acute exacerbation and granulomas in early developing stages. The study results suggest that the differences in quantity in IL-1β may be an indicator of activity of inflammation in apical periodontitis.
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