ВЗАИМООТНОШЕНИЯ ПРОВОСПАЛИТЕЛЬНЫХ ЦИТОКИНОВ И ПРОСТАГЛАНДИНА Е2 ПРИ РАЗЛИЧНОЙ РЕАКТИВНОСТИ ГИПОТАЛАМО-ГИПОФИЗАРНО-НАДПОЧЕЧНИКОВОЙ СИСТЕМЫ У ПАЦИЕНТОВ С ПОСЛЕОПЕРАЦИОННЫМИ ГРЫЖАМИ ПЕРЕДНЕЙ БРЮШНОЙ СТЕНКИ
Аннотация
С целью исследования взаимосвязи центральных и системных механизмов реактивности гипоталамо-гипофизарно-надпочечниковой системы проведен анализ динамики плазменного уровня кортизола, АКТГ, провоспалительных цитокинов и простагландина Е2 у пациентов с послеоперационными грыжами передней брюшной стенки после аллогерниопластики. Выявлены гиперреактивный и гипореактивный варианты ответа гипоталамо-гипофизарно-надпочечниковой системы. Гиперреактивный ответ ГГНС на операционную травму проявлялся на 1-е сутки после операции в виде дисбаланса прироста содержания АКТГ и кортизола, что сопровождалось снижением содержания IL-1β и TNF-α на фоне гиперпродукции PGE2. Гипореактивный ответ ГГНС проявлялся изменением функциональной обратной связи на 10-е сутки после операции и был связан с ингибированием продукции IL-1β и АКТГ, несмотря на компенсаторное повышение содержания в крови TNF-α, а также гиперсекрецией PGE2, подавляющего секрецию IL-1β для поддержания уровня кортизолемии.
Литература
1. Варюшина Е. А. Провоспалительные цитокины в регуляции процессов воспаления и репарации…автореф д.биол.наук. С-Пб; 2012. 46.
2. Змушко Е.И., Белозеров Е.С., Митин Ю.А. Клиническая иммунология. СПб: Питер; 2001. 576.
3. Клигуненко Е.Н., Лещев Д.П. Интенсивная терапия кровопотери. М.: МЕДпресс-информ; 2005. 108.
4. Овечкин А. М. Хирургический стресс-ответ, его патофизиологическая значимость и способы модуляции. Регионарная анестезия и лечение острой боли. 2008; 2: 49-62.
5. Aguilera G. Regulation of pituitary ACTH secretion during chronic stress. Front Neuroendocrinol. 1994; 15 (4): 321-350.
6. Bacou E., Haurogné K., Mignot G., Allard M., et al. Acute social stress-induced immunomodulation in pigs high and low responders to ACTH. Physiol Behav. 2017; 169: 1-8.
7. Barchitta M., Maugeri A., Favara G., et al. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. Int J Mol Sci. 2019, 20 (5): 1119. doi: 10.3390/ijms20051119
8. Biag J., Huang Y., Gou L., et al. Cyto- and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: a study of immunostaining and multiple fluorescent tract tracing. J Comp Neurol. 2012; 520 (1): 6-33.
9. Binder E.B., Nemeroff C.B. The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol Psychiatry. 2010; 15 (6): 574-588.
10. Bryan N., Ashwin H., Smart N., et al. Systemic inflammatory cytokine analysis to monitor biomaterial augmented tissue healing. Int J Artif Organs. 2015; 38 (12): 651-658.
11. Dedic N., Chen A., Deussing J. M.. The CRF Family of Neuropeptides and their Receptors – Mediators of the Central Stress Response. Curr Mol Pharmacol. 2018; 11 (1): 4-31.
12. Doolin K., Farrell C., Tozzi L. et al. Diurnal Hypothalamic-Pituitary-Adrenal Axis Measures and Inflammatory Marker Correlates in Major Depressive Disorder. Int J Mol Sci. 2017; 18 (10): 2226. doi: 10.3390/ijms18102226
13. Ferguson A.V., Latchford K.J., Samson W.K. The paraventricular nucleus of the hypothalamus – a potential target for integrative treatment of autonomic dysfunction. Expert Opin Ther Targets. 2008;12 (6): 717-727.
14. Franco A.J., Chen C., Scullen T., et al. Sensitization of the hypothalamic-pituitary-adrenal axis in a male rat chronic stress model. Endocrinology. 2016; 157: 2346-2355.
15. Gadek-Michalska A., Bugajski A.J., Bugajski J. Prostaglandins and interleukin-1b in the hypothalamic-pituitary-adrenal response to systemic phenylephrine under basal and stress conditions. Journal of physiology and pharmacology. 2008, 59, 3, 563-575.
16. Gądek-Michalska A., Tadeusz J., Bugajski A., Bugajski J. Chronic Isolation Stress Affects Subsequent Crowding Stress-Induced Brain Nitric Oxide Synthase (NOS) Isoforms and Hypothalamic-Pituitary-Adrenal (HPA) Axis Responses. Neurotox Res. 2019; 36 (3): 523-539.
17. Gadek-Michalska A., Tadeusz J., Rachwalska P., Bugajski J. Chronic stress adaptation of the nitric oxide synthases and IL-1β levels in brain structures and hypothalamic-pituitary-adrenal axis activity induced by homotypic stress. J Physiol Pharmacol. 2015; 66 (3): 427-440.
18. Gądek-Michalska A., Tadeusz J., Rachwalska P., Bugajski J. Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems. Pharmacol Rep. 2013; 65 (6): 1655-1662.
19. Golzari S.E., Nader N.D., Mahmoodpoor A. Underlying Mechanisms of Postoperative Pain After Laparoscopic Surgery. JAMA Surg. 2016; 151 (3): 295-296.
20. Goshen I., Yirmiya R. Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol. 2009; 30 (1): 30-45.
21. Hauger R.L., Risbrough V., Brauns O., Dautzenberg F.M. Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. CNS Neurol Disord Drug Targets. 2006; 5 (4): 453-479.
22. Herman J. P. Regulation of Hypothalamo-Pituitary-Adrenocortical Responses to Stressors by the Nucleus of the Solitary Tract/Dorsal Vagal Complex. Cell Mol Neurobiol. 2018; 38 (1): 25-35.
23. Itoi K., Jiang Y.Q., Iwasaki Y., Watson S.J. Regulatory mechanisms of corticotropin-releasing hormone and vasopressin gene expression in the hypothalamus. J Neuroendocrinol. 2004;16 (4): 348-355.
24. Jiang Z., Rajamanickam S., Justice N.J. Local Corticotropin-Releasing Factor Signaling in the Hypothalamic Paraventricular Nucleus. J Neurosci. 2018; 38 (8):1874-1890.
25. Joseph J.J., Golden S.H. Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus. Ann N Y Acad Sci. 2017; 1391 (1): 20-34.
26. Karnes J.M., Daffner S.D., Watkins C.M. Multiple roles of tumor necrosis factor-alpha in fracture healing. Bone. 2015; 78: 87-93.
27. Lovelock D.F., Deak T. Repeated exposure to two stressors in sequence demonstrates that corticosterone and paraventricular nucleus of the hypothalamus interleukin-1β responses habituate independently. J Neuroendocrinol. 2017; 29: e12514. doi: 10.1111/jne.12514
28. Ma Q., Cai J-L., Pan X-J., et al. Effects of neuro-immuno-modulation on healing of wound combined with local radiation injury in rats. Chin J Traumatol. 2017; 20 (5): 270-274.
29. McCann S.M., Kimura M., Karanth S., et al. Role of nitric oxide in the neuroendocrine responses to cytokines. Ann N Y Acad Sci. 1998; 840: 174-184.
30. Patel S., Maheshwari A., Chandra A. Biomarkers for wound healing and their evaluation. J Wound Care. 2016; 25 (1): 46-55.
31. Radu P., Brătucu M., Garofil D., et al. The Role of Collagen Metabolism in the Formation and Relapse of Incisional Hernia. Chirurgia (Bucur). 2015; 110 (3): 224-230.
32. Radu P., Brătucu M., Garofil D., et al. Molecular factors of failure in incisional hernia surgery. Chirurgia (Bucur). 2013; 108 (2): 193-198.
33. Ramot A., Jiang Z., Tian J.B. et al. Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress. Nat Neurosci. 2017; 20 (3): 385-388.
34. Rettori V., Fernandez-Solari J., Mohn C., et al. Nitric oxide at the crossroad of immunoneuroendocrine interactions. Ann N Y Acad Sci. 2009; 1153: 35-47.
35. Russell G.M., Kalafatakis K., Lightman S.L. The importance of biological oscillators for hypothalamic-pituitary-adrenal activity and tissue glucocorticoid response: coordinating stress and neurobehavioural adaptation. J Neuroendocrinol. 2015; 27: 378-388.
36. Stengel A., Tache Y. Neuroendocrine control of the gut during stress: corticotropin-releasing factor signaling pathways in the spotlight. Annu Rev Physiol. 2009; 71: 219-240.
37. Thankam F. G., Palanikumar G., Fitzgibbons R. J., Agrawal D. K. Molecular Mechanisms and Potential Therapeutic Targets in Incisional Hernia. Journal of Surgical Research . 2019; 236: 134-143.
38. Ulrich-Lai Y.M., Herman J.P. Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci. 2009; 10 (6): 397-409.
39. Wilson R.B. Hypoxia, cytokines and stromal recruitment: parallels between pathophysiology of encapsulating peritoneal sclerosis, endometriosis and peritoneal metastasis. Pleura Peritoneum. 2018; 3 (1): 20180103.
40. Zoccal K. F., Ferreira G. Z., Prado M. K., et al. LTB4 and PGE2 modulate the release of MIP-1α and IL-1β by cells stimulated with Bothrops snake venoms. Toxicon. 2018; 150: 289-296.
2. Змушко Е.И., Белозеров Е.С., Митин Ю.А. Клиническая иммунология. СПб: Питер; 2001. 576.
3. Клигуненко Е.Н., Лещев Д.П. Интенсивная терапия кровопотери. М.: МЕДпресс-информ; 2005. 108.
4. Овечкин А. М. Хирургический стресс-ответ, его патофизиологическая значимость и способы модуляции. Регионарная анестезия и лечение острой боли. 2008; 2: 49-62.
5. Aguilera G. Regulation of pituitary ACTH secretion during chronic stress. Front Neuroendocrinol. 1994; 15 (4): 321-350.
6. Bacou E., Haurogné K., Mignot G., Allard M., et al. Acute social stress-induced immunomodulation in pigs high and low responders to ACTH. Physiol Behav. 2017; 169: 1-8.
7. Barchitta M., Maugeri A., Favara G., et al. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. Int J Mol Sci. 2019, 20 (5): 1119. doi: 10.3390/ijms20051119
8. Biag J., Huang Y., Gou L., et al. Cyto- and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: a study of immunostaining and multiple fluorescent tract tracing. J Comp Neurol. 2012; 520 (1): 6-33.
9. Binder E.B., Nemeroff C.B. The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol Psychiatry. 2010; 15 (6): 574-588.
10. Bryan N., Ashwin H., Smart N., et al. Systemic inflammatory cytokine analysis to monitor biomaterial augmented tissue healing. Int J Artif Organs. 2015; 38 (12): 651-658.
11. Dedic N., Chen A., Deussing J. M.. The CRF Family of Neuropeptides and their Receptors – Mediators of the Central Stress Response. Curr Mol Pharmacol. 2018; 11 (1): 4-31.
12. Doolin K., Farrell C., Tozzi L. et al. Diurnal Hypothalamic-Pituitary-Adrenal Axis Measures and Inflammatory Marker Correlates in Major Depressive Disorder. Int J Mol Sci. 2017; 18 (10): 2226. doi: 10.3390/ijms18102226
13. Ferguson A.V., Latchford K.J., Samson W.K. The paraventricular nucleus of the hypothalamus – a potential target for integrative treatment of autonomic dysfunction. Expert Opin Ther Targets. 2008;12 (6): 717-727.
14. Franco A.J., Chen C., Scullen T., et al. Sensitization of the hypothalamic-pituitary-adrenal axis in a male rat chronic stress model. Endocrinology. 2016; 157: 2346-2355.
15. Gadek-Michalska A., Bugajski A.J., Bugajski J. Prostaglandins and interleukin-1b in the hypothalamic-pituitary-adrenal response to systemic phenylephrine under basal and stress conditions. Journal of physiology and pharmacology. 2008, 59, 3, 563-575.
16. Gądek-Michalska A., Tadeusz J., Bugajski A., Bugajski J. Chronic Isolation Stress Affects Subsequent Crowding Stress-Induced Brain Nitric Oxide Synthase (NOS) Isoforms and Hypothalamic-Pituitary-Adrenal (HPA) Axis Responses. Neurotox Res. 2019; 36 (3): 523-539.
17. Gadek-Michalska A., Tadeusz J., Rachwalska P., Bugajski J. Chronic stress adaptation of the nitric oxide synthases and IL-1β levels in brain structures and hypothalamic-pituitary-adrenal axis activity induced by homotypic stress. J Physiol Pharmacol. 2015; 66 (3): 427-440.
18. Gądek-Michalska A., Tadeusz J., Rachwalska P., Bugajski J. Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems. Pharmacol Rep. 2013; 65 (6): 1655-1662.
19. Golzari S.E., Nader N.D., Mahmoodpoor A. Underlying Mechanisms of Postoperative Pain After Laparoscopic Surgery. JAMA Surg. 2016; 151 (3): 295-296.
20. Goshen I., Yirmiya R. Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol. 2009; 30 (1): 30-45.
21. Hauger R.L., Risbrough V., Brauns O., Dautzenberg F.M. Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. CNS Neurol Disord Drug Targets. 2006; 5 (4): 453-479.
22. Herman J. P. Regulation of Hypothalamo-Pituitary-Adrenocortical Responses to Stressors by the Nucleus of the Solitary Tract/Dorsal Vagal Complex. Cell Mol Neurobiol. 2018; 38 (1): 25-35.
23. Itoi K., Jiang Y.Q., Iwasaki Y., Watson S.J. Regulatory mechanisms of corticotropin-releasing hormone and vasopressin gene expression in the hypothalamus. J Neuroendocrinol. 2004;16 (4): 348-355.
24. Jiang Z., Rajamanickam S., Justice N.J. Local Corticotropin-Releasing Factor Signaling in the Hypothalamic Paraventricular Nucleus. J Neurosci. 2018; 38 (8):1874-1890.
25. Joseph J.J., Golden S.H. Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus. Ann N Y Acad Sci. 2017; 1391 (1): 20-34.
26. Karnes J.M., Daffner S.D., Watkins C.M. Multiple roles of tumor necrosis factor-alpha in fracture healing. Bone. 2015; 78: 87-93.
27. Lovelock D.F., Deak T. Repeated exposure to two stressors in sequence demonstrates that corticosterone and paraventricular nucleus of the hypothalamus interleukin-1β responses habituate independently. J Neuroendocrinol. 2017; 29: e12514. doi: 10.1111/jne.12514
28. Ma Q., Cai J-L., Pan X-J., et al. Effects of neuro-immuno-modulation on healing of wound combined with local radiation injury in rats. Chin J Traumatol. 2017; 20 (5): 270-274.
29. McCann S.M., Kimura M., Karanth S., et al. Role of nitric oxide in the neuroendocrine responses to cytokines. Ann N Y Acad Sci. 1998; 840: 174-184.
30. Patel S., Maheshwari A., Chandra A. Biomarkers for wound healing and their evaluation. J Wound Care. 2016; 25 (1): 46-55.
31. Radu P., Brătucu M., Garofil D., et al. The Role of Collagen Metabolism in the Formation and Relapse of Incisional Hernia. Chirurgia (Bucur). 2015; 110 (3): 224-230.
32. Radu P., Brătucu M., Garofil D., et al. Molecular factors of failure in incisional hernia surgery. Chirurgia (Bucur). 2013; 108 (2): 193-198.
33. Ramot A., Jiang Z., Tian J.B. et al. Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress. Nat Neurosci. 2017; 20 (3): 385-388.
34. Rettori V., Fernandez-Solari J., Mohn C., et al. Nitric oxide at the crossroad of immunoneuroendocrine interactions. Ann N Y Acad Sci. 2009; 1153: 35-47.
35. Russell G.M., Kalafatakis K., Lightman S.L. The importance of biological oscillators for hypothalamic-pituitary-adrenal activity and tissue glucocorticoid response: coordinating stress and neurobehavioural adaptation. J Neuroendocrinol. 2015; 27: 378-388.
36. Stengel A., Tache Y. Neuroendocrine control of the gut during stress: corticotropin-releasing factor signaling pathways in the spotlight. Annu Rev Physiol. 2009; 71: 219-240.
37. Thankam F. G., Palanikumar G., Fitzgibbons R. J., Agrawal D. K. Molecular Mechanisms and Potential Therapeutic Targets in Incisional Hernia. Journal of Surgical Research . 2019; 236: 134-143.
38. Ulrich-Lai Y.M., Herman J.P. Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci. 2009; 10 (6): 397-409.
39. Wilson R.B. Hypoxia, cytokines and stromal recruitment: parallels between pathophysiology of encapsulating peritoneal sclerosis, endometriosis and peritoneal metastasis. Pleura Peritoneum. 2018; 3 (1): 20180103.
40. Zoccal K. F., Ferreira G. Z., Prado M. K., et al. LTB4 and PGE2 modulate the release of MIP-1α and IL-1β by cells stimulated with Bothrops snake venoms. Toxicon. 2018; 150: 289-296.
Опубликована
2019-12-02
Как цитировать
ИГНАТЕНКО, Г. А.; ЕНГЕНОВ, Н. М.; БОНДАРЕНКО, Н. Н..
ВЗАИМООТНОШЕНИЯ ПРОВОСПАЛИТЕЛЬНЫХ ЦИТОКИНОВ И ПРОСТАГЛАНДИНА Е2 ПРИ РАЗЛИЧНОЙ РЕАКТИВНОСТИ ГИПОТАЛАМО-ГИПОФИЗАРНО-НАДПОЧЕЧНИКОВОЙ СИСТЕМЫ У ПАЦИЕНТОВ С ПОСЛЕОПЕРАЦИОННЫМИ ГРЫЖАМИ ПЕРЕДНЕЙ БРЮШНОЙ СТЕНКИ.
Университетская клиника, [S.l.], n. 4(33), p. 5-13, дек. 2019.
ISSN 1819-0464. Доступно на: <http://journal.dnmu.ru/index.php/UC/article/view/383>. Дата доступа: 26 апр. 2024
doi: https://doi.org/10.26435/uc.v0i4(33).383.
Раздел
Оригинальные исследования
