MICROSTRUCTURE OF PELVIC BONE OSTEOPATITIS IN RATS OF THE PERIOD OF SENILE CHANGES TREATED WITH A HYPOCHOLESTEROLEMIC DIET AND THIRD-GENERATION CALCIUM PREPARATIONS

  • Р. В. Лопак FSBEI HE «Saint Luka Lugansk State Medical University» MOH Russia, Lugansk
  • В. И. Лузин FSBEI HE «Saint Luka Lugansk State Medical University» MOH Russia, Lugansk
  • А. А. Власова FSBEI HE «Saint Luka Lugansk State Medical University» MOH Russia, Lugansk

Abstract

In an experiment on 280 female rats of senile age, it was shown that the use of a diet with a high cholesterol content is accompanied by an increase in the level of total blood cholesterol, as well as instability of the microstructure of the pelvic bone osteoapatitis structure from the 15th day of the experiment. With an increase in the duration of the experiment, these deviations progress. The use of calcium preparations of the third generation slows down the manifestation of aging of the bone system at the level of the microstructure of osteoapatitis, and the effectiveness of the use directly depends on the spectrum and concentration of osteotropic trace elements in them. In comparison with the group without correction, the use of complex calcium preparations against the background of a hypercholesterolemic diet is accompanied by a corrective effect, the severity of which also depends on the spectrum and concentration of osteotropic trace elements in them. As the duration of administration for all drugs used increased, the effectiveness of correction increased. The most effective, according to our data, is the use of the drug Calcemin Advance.

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Published
2024-07-01
How to Cite
ЛОПАК, Р. В.; ЛУЗИН, В. И.; ВЛАСОВА, А. А.. MICROSTRUCTURE OF PELVIC BONE OSTEOPATITIS IN RATS OF THE PERIOD OF SENILE CHANGES TREATED WITH A HYPOCHOLESTEROLEMIC DIET AND THIRD-GENERATION CALCIUM PREPARATIONS. University Clinic, [S.l.], n. 2(51), p. 12-16, july 2024. ISSN 1819-0464. Available at: <http://journal.dnmu.ru/index.php/UC/article/view/2073>. Date accessed: 16 oct. 2025.
Section
Оригинальные исследования