ГАМКЕРГИЧЕСКИЕ МЕХАНИЗМЫ ПАТОГЕНЕЗА И ЛЕЧЕНИЯ ДЕПРЕССИВНОГО СИНДРОМА
Аннотация
Депрессия как болезнь цивилизации весьма экстенсивно распространяется в последние три десятилетия. Имеется выраженная тенденция, что вскоре это заболевание займет одно из первых мест в общей структуре заболеваемости. Относительно невысокая терапевтическая активность в лечении депрессивного синдрома объясняется отсутствием четких представлений о его патогенезе. Моноаминергическая гипотеза патогенеза депрессии полностью исчерпала возможности лечения заболевания. Разработанные в конце 90-х — начале 2000-х годов нейротрофическая и глутаматергическая гипотезы патогенеза депрессии расширили фармакотерапевтические возможности лечения депрессии. В тоже время, механизмы патогенеза депрессии, опосредуемые нейропередачей с помощью ɣ-аминомасляной кислоты, разработаны недостаточно. В этом обзоре рассмотрено участие рецепторов ɣ-аминомасляной кислоты типов А и В нейронов лимбических структур мозга в регуляции эмоций, в патогенезе тревожных и депрессивных расстройств. Обсуждаются возможности использования лигандов указанных рецепторов в качестве психофармакологических средств для лечения депрессии.
Литература
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Опубликована
2020-07-19
Как цитировать
АБРАМЕЦ, И. И.; ЕВДОКИМОВ, Д. В.; ЗАЙКА, Т. О..
ГАМКЕРГИЧЕСКИЕ МЕХАНИЗМЫ ПАТОГЕНЕЗА И ЛЕЧЕНИЯ ДЕПРЕССИВНОГО СИНДРОМА.
Архив клинической и экспериментальной медицины, [S.l.], v. 26, n. 1, p. 47-55, июль 2020.
ISSN 1605-9360. Доступно на: <http://journal.dnmu.ru/index.php/akem/article/view/588>. Дата доступа: 23 апр. 2024
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Научные обзоры
