INFLUENCE OF CORRECTION KETONEMIA AND GLYCEMIA LEVEL ON THE ATTRACTION TO ETHANOL IN RATS WITH FORMING ALCOHOL ADDICTION

  • А. К. Бортникова M. Gorky Donetsk national medical university

Abstract

In view of a hypoglycemia the brain of alcoholdepended animals utilizes ketonic bodies. Ethanol provokes formation of ketonic bodies. So called "wrong circle” became isolated: the ethanol using → hypoglycemia → formation of ketones → a brain food by ketones → the brain needs for ketones → an organism needs of ethanol. On alcoholreliantal rats with the expressed hypoglycemia and ketosis it is shown that artificial suppression ketosis doesn’t reduce an attraction to ethanol. On the contrary, the long metabolic correction level of glycemia, promotes weakening of a consumption of alcohol and disappearance ketosis. The conclusion is drawn that the necessitate essence to alcohol consists in dependence not from ethanol directly, and from the ketonic bodies which education is initiated by a hypoglycemia.

References

1. Колмакова Т.С. Современное представление об эпигенетических механизмах формирования наркозависимости и психических расстройств эмоциональной сферы / Т.С. Колмакова, Н.А. Григорян /Фундаментальные исследования. – 2012. – № 10 (часть 2). – С. 380-385.
2. Машковский М. Д. Лекарственные средства. 15-е изд., перераб., испр. и доп. – М.: ООО «Издательство Новая Волна», 2005. – 1206 с.
3. Основы компьютерной биостатистики: анализ информации в биологии, медицине и фармации статистическим пакетом MedStat / Лях Ю.Е., Гурьянов В.Г., Хоменко В.Н., Панченко О.А. / Донецк, Издатель Папакица Е.К., 2006. – 211 с.
4. Vendruscolo L.F., Barbier E., Schlosburg J.E. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. – J. Neurosci. – 2012. – Vol. 32, No. 22. – P. 7563-7571.
Published
2020-07-01
How to Cite
БОРТНИКОВА, А. К.. INFLUENCE OF CORRECTION KETONEMIA AND GLYCEMIA LEVEL ON THE ATTRACTION TO ETHANOL IN RATS WITH FORMING ALCOHOL ADDICTION. Архив клинической и экспериментальной медицины, [S.l.], v. 25, n. 1, p. 36-40, july 2020. ISSN 1605-9360. Available at: <http://journal.dnmu.ru/index.php/akem/article/view/549>. Date accessed: 16 oct. 2025.
Section
Оригинальные исследования