НЕЙРОХИМИЧЕСКИЕ МЕХАНИЗМЫ НАРУШЕНИЙ ПСИХИЧЕСКИХ ПРОЦЕССОВ ПРИ ДЛИТЕЛЬНОМ ВВЕДЕНИИ ГЛЮКОКОРТИКОИДОВ И ВЕРОЯТНЫЕ ПУТИ ИХ КОРРЕКЦИИ
Аннотация
Хроническое введение дексаметазона крысам с питьевой водой в суточной дозе 0,5 мг/кг в течение недели оказывало анксиогенное и продепрессивное действие, а также нарушало выработку и воспроизведение навыка условнорефлекторной реакции активного избегания. В исследованиях на горизонтальных срезах медиальной префронтальной коры крыс, получавших дексаметазон, выявлено снижение амплитуд популяционных
возбуждающих постсинаптических потенциалов пирамидных нейронов V слоя, их N-метил-D-аспартат компонентов, угнетение экспрессии длительной потенциации, но облегчениие развития длительной депрессии синаптической передачи. Используемые психофармакологическик средства лишь частично ослабляли вызываемые дексаметазоном поведенческие и нейрохимические нарушения. Только антагонист Са2 + верапамил в
умеренной степени устранял проявления десаметазоновой нейротоксичности на клеточном и организменном уровнях. Полученные данные позволяют рекомендовать верапамил для ослабления психических проявлений побочного действия массивных доз дексаметазона.
Литература
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37. Pucilowski, O., 1992. Psychopharmacological properties of calcium channel inhibitors// Psychopharmacology.– 1992.– vol. 109, No 1.– P. 12-29.
38. Radley J. J., Sisti H. M., Hao J. et al. Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex // Neuroscience.– 2004.– vol. 125, No 1.– P. 1–6.
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2. Дядык Ф. И., Багрий А. Э., Яровая Н. Ф.. Глюкокортикоидная терапия в клинической практике// Новости медицины и фармации.– 2009.– No 297.– С. 19 – 24.
3. Artola A. Diabetes-, stress-, and ageind-related changes in synaptic plasticty in hippocampus and neocortex – the same metaplastic process?// Eur. J. Pharmacol.– 2008.–vol. 585, No. 1.– P. 153 – 162.
4. Bidzinski A., Jankowska E., Pucilowski O. Antidrpressant-like action of nicardipine, verapamil and hemicholinium-3 injected into the anterior hypothalamus in the rat forced swim test//Pharmacol. Biochem. Behav.– 1990.– vol. 36, No 4.– P. 795 – 798.
5. Calton J. L., Kang M.–H., Wilson A. W., Moore S. D. NMDAreceptor-dependent synaptic activation of voltagedependent calcium channels in basolateral amygdala// J. Neurophysiol.– 2000.– vol. 83, No 2.– P. 685 – 692.
6. Cerqueira J. J., Pêgo J. M., Taipa R. et al. Morphological correlates of corticosteroid induced changes in prefrontal cortex-dependent behaviors// J Neurosci.– 2005.– vol. 25, No .– P. 7792 – 7800.
7. Cerqueira J. J., Mailliet F., Almeida O. F. et al. The prefrontal cortex as a key target of the maladaptive response to stress //J. Neurosci.– 2007.– vol. 27, No 10.– P. 2781–2787.
8. Clarke G., O`Mahony S. M., Cryan J. F., Dinan T. G. Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?// Neuropharmacol.– 2009.– vol. 24, No 3.– P. 217 – 223.
9. de Kloet E. R., M. Joëls M., F. Holsboer F. Stress and the brain: from adaptation to disease// Nat. Rev. Neurosci.– 2005.– vol. 6, No 4.– P. 463–475.
10. de Querian D. J., Roozendaal B., McGaugh J. L. Stress and glucocorticoids impair retrieval of long-term spatial memory// Nature.– 1998.– vol. 394, No 6695.– P. 787 – 790.
11. Donbolt N. C. Glutamate uptake// Progr. Neurobiol.– 2001.– vol. 65, No 1.– P. 1 – 105.
12. Goldman-Rakic P. M. Cellular basis of working memory// Neuron.– 1995.– vol. 14, No 2.– P. 477 – 485.
13. Gomes J. A., Stevens R. D., Levin J. J. et al. Glucocorticoid therapy in neurologic critical care// Crit. Care Med.– 2005.– vol. 33, No 6.– P. 1214 – 1224.
14. H aefely W . T he G ABA-benzodiazepine i nteraction: f ifteen years later// Neurochem. Res.– 1990.– vol. 15, No 2.– P. 169-174.
15. Hafezi-Moghadam A., Simoncini T., Yang Z. et al. Acute cardiovascular protective effect of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase// Nat. Med.– 2002.– vol. 8, No 5.– P. 473 – 479.
16. Handley S. L., Mithani S. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration of “fear”- motivated behaviour// Naunyn-Smiedebergs Arch. Pharmacol.– 1984.– vol. 327, No. 1.– P. 1 – 5.
17. Hartley C. A., Phelps E. A. Changing fear: the neurocircuitry of emotion regulation// Neuropsychopharmacol.– 2010.– vol.35, No 1.– P. 136 – 146.
18. Herry C, Garcia R. Prefrontal cortex long-term potentiation, but not long-term depression, is associated with the maintenance of extinction of learned fear in mice// J. Neurosci.– 2002.– vol. 22, No 2.– P. 577–583.
19. Hirsh J. C., Crepel F. Blockade of NMDA receptors unmasks a long-term depression in synaptic efficacy in rat prefrontal neurons in vitro// Exp. Brain Res.– 1991.– vol. 85, No 3.– P. 621 – 624.
20. Ilyin, V. I., Wittermore, E. R., Guastella, J. et al. (1996) Subtype selective inhibition of N–methyl-D-aspartate receptors by haloperidol// Mol. Pharmacol.– 1996.– vol. 50, No 6.– P. 1541 – 1550.
21. Izumi I., Auberson Y. P., Zorumski C. F. (2006) “Zinc modulates bidirectional hippocampal plasticity by effects on the NMDA receptors// J. Neurosci.– 2006.– vol. 26, No 27.– P. 7181 – 7188.
22. Kato A., N. Rouach N., R.A. Nicoll R. A., D.S. Bredt D. S. Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination// Proc. Natl. Acad. Sci. USA.– 2005.– vol. 102, No 6.– P. 5600–5605.
23. Keenan P. A., Jacobson M. W., Soleymani R. M. et al. The effect on memory of chronic prednisone treatment in patient with systemic disease// Neurology.– 1996.– vol. 47, No 6.– P. 1396 – 1402.
24. Knoll J., Kolemen K., Knoll B. A method for the elaborationof a non-extinguishable conditioned reflex in the rat”, Acta Physiol. Acad. Sci. Hung.– vol. 6, No. 2.– P. 327 – 345.
25. Leung D. Y., Hanifin J. M., Charlesworth E. N. et al. Disease management of atopic dermatitis: a practice parameter// Ann. Allergy Asthma Immunol.– 1997.– vol. 79, No 3.– P. 197 – 211.
26. Lin a., Hou Q., Jarzylo L. et al. Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking// J. Neurochem.– 2011.– vol. 119, No 1.– P. 27–39.
27. Liston M., Miller M., Goldwater D. S. et al. Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional setshifting// J. Neurosci.– 2006.– vol. 26, No 27.– P. 7870–7874.
28. Malenka R. C., Bear M. F. LTP and LTD: an embarrassment of riches// Neuron.– 2004.– vol. 44, No 1.– P. 5 – 21.
29. Matsumoto Y., Ohba Y., Ikeda N., Itoh M. Antidepressive action of Ca2+ channel antagonists on behavioral despair in forced swimming test in rats// Papers Kyushu Wom. Univer.– 2001.– vol. 37, No 4.– P. 27 – 34.
30. McEwen B. S. Physiology and neurobiology of stress and adaptation: central role of the brain// Physiol. Rev.– 2007.– vol. 87, No 4.– P. 873–904.
31. Mitra R., Jadhav S., McEwen B. S. et al. Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala// Proc. Natl. Acad. Sci. USA.– 2005.– vol. 102, No 10.– P. 9371–9376.
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33. Nakanishi S., Masu M. (1994) Molecular diversity and functions of glutamate receptors// Annu. Rev. Biophys. Biomol. Struct.– 1994.– vol. 23, No 3.– P. 319–348.
34. Peng L., Li B., Du T. et al. Does convential anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function?// Pharmacol. Biochem. Behav.– 2012.– vol. 100, No 4.– P. 712-725.
35. Porsolt R. D. , A. Bertin A., and M. Jalfre M. “Behavioural despair” in rats and mice: strain differences and effects of imipramine// Eur. J. Pharmacol.– 1978.– vol. 51, No. 2.– P. 291 – 294.
36. Price J. L., Drevets W. C. Neurocircuitry of mood disorders// Neuropsychopharmacol.– 2010.– vol. 35, No 1.– P. 192 – 216.
37. Pucilowski, O., 1992. Psychopharmacological properties of calcium channel inhibitors// Psychopharmacology.– 1992.– vol. 109, No 1.– P. 12-29.
38. Radley J. J., Sisti H. M., Hao J. et al. Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex // Neuroscience.– 2004.– vol. 125, No 1.– P. 1–6.
39. Radley J. J., Rocher A. B., Miller M. et al. Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex // Cereb. Cortex.– 2006.– vol. 16, No 3.– P. 313–320.
40. Rhen T., Cidlowski J. A. Antiinflammatory action of glucocorticoids – new mechanisms for old drugs// N. Engl. J. Med.–2005.– vol. 353, No 16.– P. 1711 – 1723.
41. Runyan J. D., Moore A. N., Dash P. K. A role for prefrontal cortex in memory storage for trace fear conditioning// J. Neurosci.– 2004.– vol. 24, No 5.– P. 1288–1295.
42. S ah P ., B ekkers J . M . A pical d endritic l ocationof s low afterhyperpolarization current in hippocampal pyramidal neurons: implication for the integration of long-term potentiation// J. Neurosci.– 1996.– vol. 16, No 15.– P. 4537- 4542.
43. Simons J. S., Sqiers H. J. Prefrontal and medial temporal lobe interactions in long-term memory// Nat. Rev. Neurosci.– 2003.– vol. 4, No 6.– P. 637–648.
44. Umukoro S., Ashorobi R. B., Essein E. E. 2006. Anticonvulsant and anxiolytic effects of calcium channel blockers in mice// J. Med. Sci.– 2006.– vol. 6, No 5.– P. 1021–1024.
45. Yuen E. Y., Liu W., Karatsoreos I. N. et al. Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory// Proc. Natl. Acad. Sci. USA.– 2009.– vol. 106, No 15.– P. 14075–14079.
Опубликована
2020-07-01
Как цитировать
СИДОРОВА, Ю. В.; ЕВДОКИМОВ, Д. В.; АБРАМЕЦ, И. И..
НЕЙРОХИМИЧЕСКИЕ МЕХАНИЗМЫ НАРУШЕНИЙ ПСИХИЧЕСКИХ ПРОЦЕССОВ ПРИ ДЛИТЕЛЬНОМ ВВЕДЕНИИ ГЛЮКОКОРТИКОИДОВ И ВЕРОЯТНЫЕ ПУТИ ИХ КОРРЕКЦИИ.
Архив клинической и экспериментальной медицины, [S.l.], v. 25, n. 1, p. 27-35, июль 2020.
ISSN 1605-9360. Доступно на: <http://journal.dnmu.ru/index.php/akem/article/view/548>. Дата доступа: 16 июль 2024
Раздел
Оригинальные исследования
